40-125-110MG
MilliporeSigma™ Calbiochem™ IM-412
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 40-125-110MG-Each-of-1 | In Stock | ₹ 16,024.53 |
40-125-110MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,024.53
GST (18%): ₹ 2,884.415
Total Price: ₹ 18,908.945
Color
Off-white
Molecular Formula
C16H14ClN5O2
Solubility
DMSO or EtOH
Quantity
10 mg
Description
90% by HPLC
Formula Weight
343.77g/mol
Form
Solid
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Description
- A cell permeable imidazoxanthine shown to decrease TGF-β stimulated reporter activity in a dose-dependent manner in HEK293 reporter cells, with an IC 50 of 4.1μM without cell cytotoxicity
- Inhibits TGF-β receptor I (TβRI) and TGF-β receptor II (TβRII) expression and its downstream Smad2 and Smad3 phosphorylation as well as JNK and ERK activity
- In addition, it elicits TGF-β-induced fibroblast differentiation with attenuated expression of several fibrotic markers such as α-SMA and fibronectin, and suppresses collagen accumulation in CCD-18Lu human normal lung fibroblasts.