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MilliporeSigma™ Calbiochem™ Microcystin-LR, Microcystis aeruginosa
Manufacturer: MilliporeSigma™
CAS Number: 101043-37-2
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Color
Pale Yellow
Target Proteins
PP1
Molecular Formula
C49H74N10O12
Solubility
DMSO or MeOH
Quantity
500 μg
Description
95% by HPLC
CAS
101043-37-2
Formula Weight
995.2g/mol
Form
Lyophilized
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | 101043-37-2 | MICROCYSTIN-LR | -- | -- |
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Description
- Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria Microcystis aeruginosa
- Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A)
- Unlike Okadaic Acid (Cat
- No
- 495604), microcystin-LR is effective on both PP1 (IC 50 = 1.7 nM) and PP2A (IC 50 = 40 pM)
- Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions
- Has no effect on protein kinases, making it useful for reducing the effect of contaminating phosphatase activities in protein kinase assays
- A 2.5mm (250μg/100μl) solution of Microcystin-LR, Microcystis aeruginosa (Cat
- No
- 475821) in DMSO is also available.