50-404-10001

MilliporeSigma™ Calbiochem™ CaCC Blocker IV, Benzbromarone

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 50-404-10001-Each-of-1 In Stock ₹ 7,738.90

50-404-10001 - Each of 1

₹ 7,738.90

In Stock

Quantity

1

Base Price: ₹ 7,738.90

GST (18%): ₹ 1,393.002

Total Price: ₹ 9,131.902

Color

White

Target Proteins

TMEM16A-CaCC

Formula Weight

424.1g/mol

Content And Storage

Protect from light

Quantity

100 mg

Description

97% by HPLC

Molecular Formula

C17H12Br2O3

Solubility

DMSO

Form

Powder

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Description

  • A cell-permeable uricosuric agent that, in addition to its known efficacy in gout treatment, acts as a reversible CaCC blocker and is reported to be more potent than NFA (Cat
  • No
  • 481987) and NPPB (Cat
  • No
  • 484100) in suppressing 500nM Ionomycin- (Cat
  • Nos
  • 407950, 407952, and 407953) induced I - influx in TMEM16A-expressing HEK293 cells (IC 50 = 9.97, 140, and 150μM, respectively) as well as in blocking voltage-gated Cl - current in TMEM16B-expressing HEK293 cells, while exhibiting much reduced potency against ENaC (α, β, and γ) or CFTR
  • Shown to significantly reduce mucin secretion from NHBE (normal human bronchial epithelial) and suppress human ASM (airway smooth muscle) contraction upon muscarinic receptor stimulation.