50-452-10001
MilliporeSigma™ Calbiochem™ Hhat Inhibitor, RU-SKI 43
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-452-10001-Each-of-1 | In Stock | ₹ 22,416.72 |
50-452-10001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 22,416.72
GST (18%): ₹ 4,035.01
Total Price: ₹ 26,451.73
Color
Off-white
Target Proteins
Hhat
Solubility
DMSO
Form
Semi-solid
Description
98% by HPLC
Molecular Formula
C22H30N2O2S
Content And Storage
Protect from light
Quantity
10 mg
Related Products
Description
- A cell-permeable dihydrothienopyridinyl-ethanone compound that acts as an effective inhibitor against MBOAT family member Hhat/hedgehog acyltransferase-catalyzed ShhN palmitoylation in a palmitoyl CoA-noncompetitive ( K i = 6,9μM; [ShhN] = 38μM) and ShhN-uncompetitive ( K i = 7.4μM; [palmitoyCoA] = 30μM) manner
- Effectively prevents Shh- & Hhat-transfected COS-1 cells from activating hedgehog signaling in co-cultured C3H10T1/2 cells (∽80% inhibition with10μM inhibitor) by inhibiting COS-1 intracellular ShhN palmitoylation (by 52% and 80%, respectively, with 10 or 20μM drug treatment) without affecting cellular palmitoylation of H-ras & fyn, myristoylation of c-Src & Wnt3a, Shh autoprosessing, or the protein level and localization of Shh & Hhat
- Exhibits short plasma half-life in mice ( t 1/2 = 17 min; i.v.).