50-602-80001
MilliporeSigma™ Calbiochem™ Cell Proliferation Inducer, WS3
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-602-80001-Each-of-1 | In Stock | ₹ 22,416.72 |
50-602-80001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 22,416.72
GST (18%): ₹ 4,035.01
Total Price: ₹ 26,451.73
Color
Tan
Description
98% by HPLC
Solubility
DMSO or H2O
Form
Solid
Formulation
Supplied as a hydrochloride salt.
Molecular Formula
C28H30F3N7O3·HCl
Content And Storage
Protect from light
Quantity
10 mg
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Description
- A cell-permeable, diarylurea analog that can reversibly induce cell proliferation of primary retinal pigment epithelial (RPE) cells from rodents and from fetal and adult human donors (∽ 25nM)
- Its action suggested to be mediated through Erb3 binding protein 1 (Ebp1)
- Non-proliferating RPE cells at passage 6 appear to respond well to WS3 treatment, whereas actively proliferating cells in passage 1 to 4 do not exhibit any increase in proliferation
- These cells can differentiate into functional monolayer following WS3 withdrawal
- However, WS3-expanded adult human RPE cells differentiate less effectively when compared to stem cell-derived RPE cells
- The expanded RPE cells are shown to preserve vision when transplanted into rodent models of retinal degeneration
- Also shown to induce proliferation of mouse R7T1 β cells (EC 50 = 74nM)
- Not reported to induce any genetic changes or tumorigenic events.