50-617-310MG
MilliporeSigma™ Calbiochem™ p38 MAP Kinase Inhibitor XI
Manufacturer: MilliporeSigma™
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Color
Light Beige
Molecular Formula
C21H14F2N2O
Solubility
DMSO
Form
Powder
Description
98% by HPLC
Formula Weight
348.4g/mol
Content And Storage
Hygroscopic, Protect from light
Quantity
10 mg
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Description
- A cell-permeable naphthyridine N-oxide compound that acts as a potent, reversible p38α MAP kinase inhibitor (IC 50 = 68nM) and exhibits excellent selectivity among 54-kinases
- It acts on the ATP-binding site plus an adjacent hydrophobic pocket
- Exhibits desirable ADME (Absorption, Distribution, Metabolism, and Excretion) profile with good microsomal stability, low toxicity, and low reactivity towards cytochrome P450 isozymes
- Shown to inhibit lipopolysaccharide-induced TNFα production in a dose-dependent manner (ED 50 of 0.5mg/kg).