52-123-31MG
MilliporeSigma™ Calbiochem™ PDGFR Tyrosine Kinase Inhibitor IV
Manufacturer: MilliporeSigma™
CAS Number: 627518-40-5
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 52-123-31MG-Each-of-1 | In Stock | ₹ 22,793.18 |
52-123-31MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 22,793.18
GST (18%): ₹ 4,102.772
Total Price: ₹ 26,895.952
Color
Off-white
Target Proteins
PDGFR Tyrosine Kinase
Molecular Formula
C18H16FN3O2
Solubility
DMSO or MeOH
Form
Solid
Description
98% by HPLC
CAS
627518-40-5
Formula Weight
325.3g/mol
Content And Storage
Protect from light
Quantity
1 mg
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris™ JNJ 10198409 | -- | -- | |
| | Tocris™ JNJ 10198409 | -- | ₹ 27,789.89 | |
| | Tocris™ JNJ 10198409 | -- | ₹ 1,16,022.78 | |
| | Biotang Inc JNJ-10198409, Free Base, > 99%, 25MG, CAS#627518-40-5, M.W.325.34, PDGF Receptor Tyrosine Kinase Inhibitor IV; RWJ-540973. RS323-25MG | -- | ₹ 80,193.68 | |
| | Sigma Aldrich Fine Chemicals Biosciences JNJ-10198409 >=98% (HPLC), solid | 627518-40-5 | 1MG | -- | ₹ 25,888.74 | |
| | 627518-40-5 | N-(3-Fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine | -- | ₹ 2,224.56 - ₹ 11,293.92 |
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Description
- A cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC 50 < 33nM)
- Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC 50 = 4.2nM and 45nM for -β and -α, respectively) and c-Abl (IC 50 = 22nM)
- Exhibits less activity towards Lck, c-Src, and Fyn (IC 50 = 100 nM, 185nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR (IC 50 = 3.1μM, > 10μM, > 10μM, 45.8μM and > 100μM, respectively).