53-155-20001
MilliporeSigma™ Calbiochem™ Argonaute-2 Inhibitor, BCI-137
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 53-155-20001-Each-of-1 | In Stock | ₹ 24,589.09 |
53-155-20001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 24,589.09
GST (18%): ₹ 4,426.036
Total Price: ₹ 29,015.126
Color
Gray-white
Target Proteins
Argonaute-2
Solubility
DMSO
Form
Solid
Description
97% by HPLC
Molecular Formula
C11H11N3O6S
Content And Storage
Protect from light
Quantity
25 mg
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Description
- A cell-permeable, non-toxic dioxotetrahydroquinoxaline compound that mimics uridine and directly and reversibly interacts with the microRNA (miRNA) binding domain of Argonaute-2 (Ago2; K D = 126μM) and significantly inhibits binding of miR-20a, miR-26a, miR-107, miR-223, and let-7a to Ago2
- However, it does not affect Ago2 stability in cells
- Displaces Ago2 from the miR-155 host gene promoter region (70% reduction in Ago2 association) and increases histone H4 acetylation (∽300%) in NB4 leukemia cell line
- Promotes retinoic acid-induced differentiation of NB4 cells to granulocytes
- Please note that the molecular weight for this compound is batch-specific due to variable water content.