53-166-00001
MilliporeSigma™ Calbiochem™ GCase Activator, NCGC00188758
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 53-166-00001-Each-of-1 | In Stock | ₹ 20,137.40 |
53-166-00001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 20,137.40
GST (18%): ₹ 3,624.732
Total Price: ₹ 23,762.132
Color
Light Orange
Target Proteins
Glucocerebrosidase (Gcase)
Solubility
DMSO
Form
Powder
Description
98% by HPLC
Molecular Formula
C17H14N4O
Content And Storage
Protect from light
Quantity
10 mg
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Description
- A cell-permeable pyrazolopyrimidine-carboxamide compound that directly binds to glucocerebrosidase (GCase; K d ∽ 9μM for NT-467 fluorescent labeled GCase) and enhances its activity and serves as a chaperone for its translocation to the lysosomal compartment in fibroblasts of patients with Gaucher disease (AC 50 = 5.2 and 6.5μM for wild type and mutant N370S, respectively)
- Also shown to be effective in increasing GCase activity in macrophages from Gaucher's disease patients as well as in iPSC-derived macrophages (10.7 and 3.2 fold, respectively)
- Normalizes reactive oxygen species production and improves chemotaxis in Gaucher disease macrophages
- Shown to permeate the blood-brain barrier
- Exhibits desirable pharmacokinetic properties with plasma t 1/2 = 19.3 h and C max of 1.03μM (following a single injection of 50mg/kg in mice)
- Please note that the molecular weight for this compound is batch-specific due to variable water content.