53-258-30001
MilliporeSigma™ Calbiochem™ TLR1/TLR2 Agonist II, CU-T12-9
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 53-258-30001-Each-of-1 | In Stock | ₹ 21,595.34 |
53-258-30001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 21,595.34
GST (18%): ₹ 3,887.161
Total Price: ₹ 25,482.501
Color
Yellow
Target Proteins
TLR1/TLR2
Solubility
DMSO
Form
Powder
Description
98% by HPLC
Molecular Formula
C17H13F3N4O2
Content And Storage
Protect from light
Quantity
10 mg
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Description
- A diphenyl substituted imidazole based compound that directly and selectively targets TLR1/2 and induces their dimerization and activates TLR1 and 2 signaling leading to NF-κB and AP-1 activation ( K D = 182 and 478 nM, respectively; EC 50 = 52.9nM for TLR2 in HEK-Blue cells over-expressing hTLR2)
- Does not affect the dimerization of TLR2/TLR6 and exhibits poor affinity towards TLR3, TLR4, TLR5, TLR7 and TLR8
- Shown to compete with Pam 3 CSK 4 (Cat
- No
- 506350; K i = 45.4nM) for binding to TLR1/2 interface and enhance heterodimerization
- Up-regulates the expression of TLR1, TLR2, TNFα, IL-10, and iNOS in RAW 264.7 macrophages in a time-dependent manner
- Shown to be non-toxic up to 100μM concentration
- Please note that the molecular weight for this compound is batch-specific due to variable water content.