53-962-0250NG
MilliporeSigma™ Calbiochem™ PP2A Inhibitor II, GST-Fusion, Human, Recombinant,E.coli
Manufacturer: MilliporeSigma™
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Formulation
In 50 mM Tris-HCl, 14 mM βME, 1 mM benzamidine, 1 mM EDTA, 0.1 mM PMSF, 10% glycerol, pH 7.4.
Target Proteins
PP2A
Content And Storage
Avoid Freeze-Thaw Cycles
Quantity
250 NG
Description
90% by SDS-PAGE
Formula Weight
67000g/mol
Form
Liquid
Related Products
Description
- Recombinant, human PP2AI I 2 fused to GST and expressed in E
- coli
- Inhibits protein phosphatase 2A (PP2A) potently with K i ∽ 25-30nM with myelin basic protein, histone H1, and other substrates of PP2A but not with casein as a substrate
- Stimulates PP1
- Prevents inhibition of E-Cdk-2 by p21 Cip1
- Associates with B cyclin
- Regulates histone binding to DNA, transcriptional activity and chromatin condensation
- Undergoes phosphorylation in cells
- Highly expressed in some cancers
- Associates with HRX leukemia-associated fusion proteins
- Occurs as fusion protein in acute undifferentiated leukemia
- Does not inhibit PP1, PP2B, PP2C, or pyruvate dehydrogenase.