55-752-1500UG

MilliporeSigma™ Calbiochem™ InSolution™ Ro-31-8220

Manufacturer: MilliporeSigma™

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Color

Clear Orange-brown

Description

95% by HPLC

Molecular Formula

C25H23N5O2S·CH3SO3H

Content And Storage

Protect from light

Quantity

500 μg

Formulation

A 5 mM (500μg/181μl) solution of Ro-31-8220 in H2O.

Target Proteins

PKC

Formula Weight

553.7g/mol

Form

Liquid

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Description

  • A competitive, selective inhibitor for protein kinase C (IC 50 = 10nM) over protein kinase A (IC 50 = 900nM), Ca 2+ /calmodulin-dependent protein kinase (IC 50 = 17μM) and phosphorylase protein kinase
  • Inhibits TPA induced p47 phosphorylation in platelets (IC 50 = 700nM)
  • Also inhibits CD3 downregulation in T cells (IC 50 = 500nM).