R&D Systems™ Human/Mouse Ephrin Sampler Pack Protein Sampler Pack

Description

• Description The Eph receptors represent the largest family of receptor tyrosine kinases (RTK) in the human genome
• Their ligands, the ephrins, are also cell surface bound proteins, thereby requiring cell-cell interaction for binding and signaling
• The ephrin ligands are divided into two categories: the A class are tethered to the membrane by a GPI anchor, and the B class are transmembrane proteins
• Likewise, the receptors are also divided into two categories based on sequence similarity and ligand specificity
• Ephrin-A ligands bind EphA receptors and ephrin-B ligands bind EphB receptors, with the exception of EphA4 which binds both A and B-type ligands
• Eph/ephrin signaling is involved in vascular development, tissue-border formation, brain boundaries, cell migration, axon guidance, and synaptic plasticity
• Eph/ephrin signaling activation generally results in repulsion of cells and often converges on the regulation of the cytoskeleton
• Like most RTKs, ligand binding induces forward signaling, where a response occurs in the Eph receptor-containing cell
• However, in some circumstances, this family can also exhibit reverse signaling where ephrins act as receptors responding to Eph signals, and ephrins signal back into their host cell.