A5844
Monoclonal Anti-c-Abl antibody produced in mouse
clone ABL-148, ascites fluid
Manufacturer: Sigma Aldrich
Synonym(S): Anti-ABL, Anti-BCR-ABL, Anti-CHDSKM, Anti-JTK7, Anti-bcr/abl, Anti-c-ABL, Anti-c-ABL1, Anti-p150, Anti-v-abl
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 0.2 ML | A5844-0.2-ML | In Stock | ₹ 57,886.50 |
A5844 - 0.2 ML
In Stock
Quantity
1
Base Price: ₹ 57,886.50
GST (18%): ₹ 10,419.57
Total Price: ₹ 68,306.07
biological source
mouse
Quality Level
200
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
ABL-148, monoclonal
mol wt
antigen 145 kDa
species reactivity
monkey, rat, human, mouse, bovine
technique(s)
flow cytometry: suitableimmunocytochemistry: suitableimmunoprecipitation (IP): suitablemicroarray: suitablewestern blot: 1:2,000 using human melanoma cell extract
isotype
IgG2a
Related Products
Description
- General description: The c-Abl protein contains three high mobility group-like domains that bind to AT-rich DNA in a cooperative manner.
- Specificity: Mouse anti-c-Abl antibody reacts specifically with an epitope present in the SH2 domain of the c-Abl. The product has also shown reactivity for c-Abl of monkey, rat, bovine, mouse and human.
- Immunogen: recombinant c-Abl, SH2 domain.
- Application: Monoclonal anti-c-Abl antibody can be used in western blotting (diluted 1:2000) using melanoma cell extract from human. It can also be used in microarray and flow cytometry. Monoclonal anti-c-Abl antibody can be used for studying the mechanism of signaling pathways involving c-Abl. It may also be used for immunoprecipitation and immunocytochemistry.
- Biochem/physiol Actions: Cytoplasmic c-Abl regulates SH2/SH3 adaptor protein cytoskeleton-associated adaptor protein (Crk) and the Crk-binding protein p130cas. Nuclear c-Abl has been implicated in the regulation of cell cycle-dependent and DNA damage-induced gene expression.
- Target description: c-Abl is a non-receptor tyrosine kinase with both cytoplasmic and nuclear functions. The Abl oncogen has been implicated in several human leukemias including nearly all chronic myelocytic leukemias.
- Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
SAFETY INFORMATION
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable