D4008

Dansylcadaverine

≥97% (TLC)

Manufacturer: Sigma Aldrich

CAS Number: 10121-91-2

Synonym(S): N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide, N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine, Monodansyl cadaverine

Select a Size

Pack Size SKU Availability Price
100 MG D4008-100-MG In Stock ₹ 5,194.80
250 MG D4008-250-MG In Stock ₹ 9,867.90
1 G D4008-1-G In Stock ₹ 26,773.20

D4008 - 100 MG

₹ 5,194.80

In Stock

Quantity

1

Base Price: ₹ 5,194.80

GST (18%): ₹ 935.064

Total Price: ₹ 6,129.864

Quality Level

100

Assay

≥97% (TLC)

form

powder

storage temp.

−20°C

SMILES string

CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN

InChI

1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3

InChI key

MLEBFEHOJICQQS-UHFFFAOYSA-N

Related Products

Img

Sigma Aldrich

30432

suitable for fluorescence, BioReage...

Img

Sigma Aldrich

S5628

powder...

Img

Sigma Aldrich

94498

≥85% (HPLC)...

Img

Sigma Aldrich

C3105

≥95% (HPLC), solid...

Img

Sigma Aldrich

N0758

esterase substrate, fluorogenic, ≥9...

Img

Sigma Aldrich

C3355

≥95% (HPLC), solid...

Img

Sigma Aldrich

90101

for fluorescence, ≥98.0% (HPLC)...

Img

Sigma Aldrich

A0156

≥90%, powder...

Description

  • General description: Dansylcadaverine, also called as monodansylcadaverine (MDC), is a lysosomotropic agent. It is present in acidic and lipid rich regions. Dansylcadaverine also acts as a solvent polarity probe.[1] It inhibits vesicular transport and decreases the rotavirus sequestering in L cells, when pre-treated.[2]
  • Application: Dansylcadaverine in methanol has a reported λex of 335 nm and λem of 512 nm. It has been used:as an endocytosis inhibitor in human proximal tubular HK-2 cells,(62) mouse J774A.1 macrophages and human A549 epithelial cells(63) to label autophagic vacuoles in cardiomyocytes for fluorescence microscopy studies(64)in monodansylcadaverine (MDC) staining of fibroblasts in Ankylosing spondylitis (AS) samples(65)
  • Biochem/physiol Actions: The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.
  • Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
  • Other Notes: Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid.

SAFETY INFORMATION

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves