646547
Tris(2-carboxyethyl)phosphine hydrochloride solution
0.5 M, pH 7.0(aqueous solution; pH was adjusted with ammonium hydroxide)
Manufacturer: Supelco
CAS Number: 51805-45-9
Synonym(S): TCEP
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 X 1 ML | 646547-10-X-1-ML | In Stock | ₹ 14,516.33 |
646547 - 10 X 1 ML
In Stock
Quantity
1
Base Price: ₹ 14,516.33
GST (18%): ₹ 2,612.939
Total Price: ₹ 17,129.269
Quality Level
200
concentration
0.5 M
refractive index
n20/D 1.367
pH
7.0(aqueous solution; pH was adjusted with ammonium hydroxide)
density
1.041 g/mL at 25 °C
SMILES string
Cl.OC(=O)CCP(CCC(O)=O)CCC(O)=O
InChI
1S/C9H15O6P.ClH/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15;/h1-6H2,(H,10,11)(H,12,13)(H,14,15);1H
InChI key
PBVAJRFEEOIAGW-UHFFFAOYSA-N
Other Options
Related Products
Description
- General description: It belongs to the trialkylphosphine class.[1]
- Application: Tris (2-carboxyethyl) phosphine (TCEP) can be used in several downstream applications including SDS-PAGE, mass spectrometry, labeling with cysteine specific tags, and modification of cysteine containing compounds. It prevents oxidation of protein samples, which makes it a useful buffer component as it helps to preserve enzymatic activity.[4][5][6] It has been used in the reduction and measurement of glutathione.[7]
- Biochem/physiol Actions: As a non-mercaptan reducing agent, it avoids the toxicity inherent in thiol-containing compounds. It is capable of disrupting the botulinum neurotoxin B heavy-chain/light-chain complex that is held together by a single disulfide bond, and that is responsible for endocytosis, and ultimately the toxicity, of the toxin. Since disulfide-coupled subunits are characteristic of many toxins (e.g., ricin, snake venom, and all BoNT serotypes), it may be useful as a rescue prophylactic in cases of toxin administration.[11]
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves