Desmin, Mouse anti-Rat, Mouse, Human, Clone: 4C12.1, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT53525UG-Each-of-1 | In Stock | ₹ 16,456.61 |
MABT53525UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
Desmin
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Rat, Mouse, Human
Form
Purified
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
4C12.1
Dilution
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Desmin in mouse heart, mouse skeletal muscle, rat heart, and rat skeletal muscle tissues.Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Desmin in human heart and human skeletal muscle tissues.
Gene Symbols
DES
Immunogen
GST/His-taged recombinant fragment corresponding to 64 amino acids from the C-terminal region of human Desmin.
Quantity
25 μg
Research Discipline
Cell Structure
Test Specificity
Clone 4C12.1 specifically detects Desmin in human, mouse, and rat muscles. It targets an epitope within 64 amino acids from the C-terminal end.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG2b κ
Related Products
Description
- Anti-Desmin Antibody, clone 4C12.1, Cat
- No
- MABT535, is a mouse monoclonal antibody that targets Desmin in Human, Mouse, and Rat and it is tested for use in Immunohistochemistry (Paraffin) and Western Blotting
- Desmin (UniProt: P17661) is encoded by the DES gene (Gene ID: 1674) in human
- Desmin is a major class III intermediate filament protein essential for the structural integrity and function of muscle
- In adult striated muscle desmin forms a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures
- It may also act as a sarcomeric microtubule-anchoring protein and specifically associate with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction
- Desmin is particularly abundant at the myotendinous junctions and at the neuromuscular junctions of skeletal muscle
- Mammalian cardiac muscle cells contain higher amounts of desmin (up to 2% of total protein) compared to skeletal muscle cells (0.35% of total protein)
- Mutations in DES gene have been linked to familial cardiac and skeletal myopathy characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, and restrictive heart failure
- It can also lead to myofibrillar destruction with intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells
- (rEF.: Denise Paulin, D., and Li, Z (2004)
- Experimental Cell Research 301(1); 1 -7).