FOXK1 (MNF), Rabbit anti-Human, Polyclonal, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABE132525UG-Each-of-1 | In Stock | ₹ 16,456.61 |
ABE132525UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
FOXK1 (MNF)
Classification
Polyclonal
Dilution
Western Blotting Analysis: 2 μg/mL from a representative lot detected FOXK1 (MNF) in HepG2 cell lysate. Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected FOXK1 (MNF) in human cerebral cortex, human liver, and human testis tissues.
Gene Alias
Forkhead box protein K1;Myocyte nuclear factor;MNF
Host Species
Rabbit
Molecular Weight of Antigen
∽95 kDa observed; 75.46 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity
25 μg
Research Discipline
Epigenetics & Nuclear Function
Test Specificity
This rabbit polyclonal antibody detects Forkhead box protein K1 in human cells. It targets an epitope within 20 amino acids from the C-terminal region.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide
Gene Symbols
FOXK1;MNF
Immunogen
KLH-conjugated linear peptide corresponding to 20 amino acids from the C-terminal region of human Forkhead box protein K1.
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Isotype
IgG
Related Products
Description
- Anti-FOXK1 (MNF), Cat
- No
- ABE1325, is a highly specific rabbit polyclonal antibody that targets Forkhead box protein K1 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting
- Forkhead box protein K1 (UniProt: P85037; also known as Myocyte nuclear factor, MNF) is encoded by the FOXK1 (also known as MNF) gene (Gene ID: 221937) in human
- Forkhead box protein K1 is a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene
- It is an important regulatory factor of the myogenic progenitor cell population
- It is involved in the cell cycle process and promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells
- It is shown to represses myogenic differentiation by inhibiting MEFC activity and has a role in remodeling processes of adult muscles that occur in response to physiological stimuli
- It is shown to be essential for correct temporal orchestration of molecular and cellular events necessary for muscle repair
- Forkhead box protein K1 is expressed both developing and adult tissues
- In adults, significant expression is seen in tumors of the brain, colon, and lymph node
- Two isoforms of Forkhead box protein K1 have been reported that are produced by alternative splicing
- Both FOXK1 and FOXK2 proteins are shown to act as transcriptional repressors of autophagy in muscle cells and fibroblasts
- They specifically recruit Sin3A HDAC complexes to restrict acetylation of histone H4 and expression of critical autophagy genes
- The loss of FOXK1 and FOXK2 proteins results in the upregulation of several genes controlling the initiation and nucleation of autophagosome formation
- (Ref.: Bowman, CJ., et al
- (2014)
- Nature Cell Biology 16(12); 1202-1214).