PEP246
Mouse APS, Synthetic Peptide, Invitrogen™
Manufacturer: Thermo Scientific
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Gene ID (Entrez)
23921
Purification Method
purified
Common Name
Mouse APS
Content And Storage
-20°C
Format
Lyophilized
For Use With (Application)
Blocking Assay, Control
Gene Symbol
Sh2b2
Preservative
No preservative
Quantity
50 μg
Species
Mouse
Accession Number
Q9JID9
Concentration
1 mg/mL
Description
Synthetic Peptide
Formulation
water with no preservative
Gene Alias
Alpha-1-antiproteinase S, Alpha-1-antitrypsin, Alpha-1-proteinase inhibitor
Lyophilized
Yes
Product Type
Peptide
Regulatory Status
RUO - research use only
Related Products
Description
- SH2B2/APS Synthetic Peptide, PEP-246, from Invitrogen™
- APS (adapter protein with Pleckstrin homology and Src homology 2 domains) a member of the Lnk family, is an adaptor protein that is involved in B-cell signaling, insulin signaling, cytoskeletal reorganization
- It is tyrosine phosphorylated by JAK2, KIT and other kinases during B-cell receptor stimulation of many different cytokines, chemokines and leukokines
- APS has been shown to inhibit the JAK-STAT pathway in collaboration with c-Cbl
- It is located in the cytoplasm in pre-PDGF (platelet derived growth factor) stimulated cells and localizes to the plasma membrane and peripheral regions upon PDGF stimulation
- This protein is expressed in B-cells and mast cells when detected in haematopoietic cell lines yet is also expressed in many different tissues including spleen, prostrate, testis, uterus, small intestine and skeletal muscle
- This peptide corresponds to amino acids E(605) ATLGRARAVENQYS (619) from mouse APS and can be used as a blocking peptide with polyclonal antibody PA1-1062.