PEP293
beta-2 Adaptin, Synthetic Peptide, Invitrogen™
Manufacturer: Thermo Scientific
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Gene ID (Entrez)
140670, 163, 282183, 71770
Purification Method
purified
Common Name
beta-2 Adaptin
Content And Storage
-20°C
Format
Lyophilized
For Use With (Application)
Blocking Assay, Control
Gene Symbol
AP2B1
Preservative
No preservative
Quantity
50 μg
Species
Bovine, Human, Mouse, Rat
Accession Number
P62944, P63009, P63010, Q9DBG3
Concentration
1 mg/mL
Description
Synthetic Peptide
Formulation
water with no preservative
Gene Alias
AP-2 complex subunit beta-1, Adapter-related protein complex 2 beta-1 subunit
Lyophilized
Yes
Product Type
Peptide
Regulatory Status
RUO - research use only
Related Products
Description
- AP2B1/Beta-2 adaptin Synthetic Peptide, PEP-293, from Invitrogen™
- Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated
- During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane
- There are two characterized adaptors AP1 and AP2
- AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor
- AP2 is composed of four subunits, two separate ∼100 kDa gene products with similar domain structures (alpha and beta adaptin) and a ∼50 and ∼17 kDa subunit
- There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression
- This peptide corresponds to amino acids I(588) HRKHLPIHHGSTDAGDSP (606) of human beta Adaptin 2 and can be used as a blocking peptide with polyclonal antibody PA1-1066
- This sequence is identical in human, mouse, rat and bovine.