15361
Bleomycin sulfate from Streptomyces verticillus
for fluorescence, mixture of bleomycin sulfate salts, lyophilized, powder or crystals, white to off-white
Manufacturer: Sigma Aldrich
CAS Number: 9041-93-4
Synonym(S): Blenoxane, Bleo, Blexane
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | 15361-1-MG | In Stock | ₹ 21,671.65 |
| 10 MG | 15361-10-MG | In Stock | ₹ 99,871.45 |
15361 - 1 MG
In Stock
Quantity
1
Base Price: ₹ 21,671.65
GST (18%): ₹ 3,900.897
Total Price: ₹ 25,572.547
biological source
Streptomyces verticillus
Quality Level
200
grade
for fluorescence
form
powder or crystals
quality
lyophilized
color
white to off-white
solubility
H2O: 20 mg/mL, clear, colorless
cation traces
Cu: ≤0.1%
antibiotic activity spectrum
Gram-negative bacteriaGram-positive bacterianeoplastics
Mode of action
DNA synthesis | interferes
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Lkt Laboratories CAS 9041-93-4, ≥90%, Mixture of glycopeptide bleomycin sulfate salts that induces DNA strand breaks and is used to treat various cancers. | -- | ₹ 25,818.59 | |
| | Selleck Chemical LLC Bleomycin Sulfate 10mg 9041-93-4 NSC125066 | -- | ₹ 20,431.73 | |
| | Cayman Chemical Bleomycin (sulfate) | 9041-93-4 | MFCD00070310 | 1 mg | -- | ₹ 3,730.42 | |
| | Cayman Chemical Bleomycin (sulfate), 9041-93-4, 50 mg | -- | ₹ 46,407.74 | |
| | Sigma Aldrich Fine Chemicals Biosciences Bleomycin sulfate United States Pharmacopeia (USP) Reference Standard | 9041-93-4 | 15MG | -- | ₹ 91,369.52 | |
| | Bleomycin sulfate | -- | ₹ 21,974.75 | |
| | Bleomycin sulfate | -- | ₹ 82,648.88 | |
| | Bleomycin sulfate from Streptomyces verticillus | -- | ₹ 1,06,539.65 | |
| | Bleomycin sulfate from Streptomyces verticillus | -- | ₹ 1,56,020.73 | |
| | Bleomycin sulfate from Streptomyces verticillus | -- | ₹ 1,32,032.53 |
Related Products
Description
- General description: Chemical structure: glycopeptide
- Application: Bleomycin sulfate is used to study tumor-specific cytotoxic activity in certain cell lines such as human normal oral cells(gingival fibrobast HGF, pulp cell HPC and periodontal ligament fibroblast HPLF), human oral squamous cell carcinoma (HSC-2, HSC-3, HSC-4, Ca9-22 and NA) and human promyelocytic leukemia HL-60 cells[1]. It is used to study free radical-mediated mechanisms of DNA strand scission/breaking and as a transformed cell selection agent, especially for plant transformants. Recommended for use as a selection agent at 10-100 μg/ml.
- Biochem/physiol Actions: Bleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.
- Packaging: Packaged in a bottomless glass bottle with its contents inside an inserted fused cone.
- Components: This product is a mixture of glycopeptides antibiotics containing Bleomycin A2 (70%) and B2(30%). Bleomycins differ from each other in the terminal amine and show varying biological activity.
- Caution: This product should be stored at 2-8°C.
- Preparation Note: The product is soluble in water in water at 20 mg/mL and is active for several days. A solution of 2 units/mL in 0.1 M neutral potassium phosphate should be used within 14 days. A solution is active for three months at 3 units/mL in normal saline.
- Other Notes: Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Carc. 2 - Muta. 1B - Repr. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves