A4888
Amphotericin B from Streptomyces sp.
~80% (HPLC), powder
Manufacturer: Sigma Aldrich
CAS Number: 1397-89-3
Synonym(S): LNS-AmB, NSC 527017, Fungizone
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | A4888-100-MG | In Stock | ₹ 11,344.60 |
| 250 MG | A4888-250-MG | In Stock | ₹ 19,311.80 |
| 500 MG | A4888-500-MG | In Stock | ₹ 23,457.78 |
| 1 G | A4888-1-G | In Stock | ₹ 57,156.00 |
| 5 G | A4888-5-G | In Stock | ₹ 1,36,643.98 |
| 100 G | A4888-100-G | In Stock | ₹ 17,66,791.55 |
A4888 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 11,344.60
GST (18%): ₹ 2,042.028
Total Price: ₹ 13,386.628
biological source
Streptomyces sp.
Quality Level
300
Assay
~80% (HPLC)
form
powder
color
yellow to orange
solubility
DMF: 2-4 mg/mLDMSO: 30-40 mg/mLH2O: insolublewater: insoluble
antibiotic activity spectrum
fungiyeast
Mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\2)C[C@H](O)[C@H]3C(O)=O)[C@@H](O)[C@@H](N)[C@@H]1O
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris™ Amphotericin B | -- | ₹ 26,266.92 | |
| | TOKU-E Amphotericin B, Solubilized, Lyophilized, 1397-89-3, 250 mg | -- | ₹ 9,839.40 | |
| | TOKU-E Amphotericin B, USP, 1397-89-3, 250 mg | -- | ₹ 4,953.92 | |
| | TOKU-E Amphotericin B, USP, 1397-89-3, 1 g | -- | ₹ 15,743.04 | |
| | TOKU-E Amphotericin B, Solubilized, Lyophilized, 1397-89-3, 500 mg | -- | ₹ 17,967.60 | |
| | Sigma Aldrich Fine Chemicals Biosciences Amphotericin B for microbiological assay European Pharmacopoeia (EP) Reference Standard | 1397-89-3 | | -- | ₹ 16,350.52 | |
| | Amphotericin B Pharmaceutical Secondary Standard, MilliporeSigma™ Supelco™ | -- | ₹ 40,469.88 | |
| | Sigma Aldrich Fine Chemicals Biosciences Amphotericin B United States Pharmacopeia (USP) Reference Standard | 1397-89-3 | 125MG | -- | ₹ 39,199.31 | |
| | VETRANAL™ Amphotericin B trihydrate, MilliporeSigma™ Supelco™ | -- | ₹ 16,940.88 | |
| | eMolecules Medchem Express / Amphotericin B / 100mg / 446272303 / HY-B0221 / / 1397-89-3 / MFCD00877763 / 924.091 / C47H73NO17 | -- | ₹ 6,926.94 |
Related Products
Description
- General description: Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. and has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes.
- Application: Amphotericin B is used to study the affects of the influx of calcium on antifungal activity, [1] and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers [2][3]. It is also commonly used in tissue culture as an antifungal supplement.Amphotericin B from Streptomyces sp. has been used-for amphotericin perforated patch technique[4]as a reference antifungal drug during MIC (minimum inhibitory concentration) agar dilution assay[5][6][7]as a component of Arcobacter selective isolation broth[8]
- Biochem/physiol Actions: Mode of Action: Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out.Antimicrobial spectrum: Includes fungi and yeast
- Features and Benefits: High quality antibiotic suitable for mulitple research applications
- Preparation Note: Amphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility.Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.
- Storage and Stability: Tightly closed. Dry. Keep in a well -ventilated place. Keep locked up or in an area accessible
- Other Notes: For additional information on our range of Biochemicals, please complete this form.
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
STOT RE 1
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves