P1004

Polymyxin B sulfate salt

Manufacturer: Sigma Aldrich

CAS Number: 1405-20-5

Synonym(S): Polymixin, Polymixin B, Polymixin B sulfate

Select a Size

Pack Size SKU Availability Price
1000000 UNITS P1004-1000000-UNITS In Stock ₹ 5,282.60
5000000 UNITS P1004-5000000-UNITS In Stock ₹ 11,517.80
10000000 UNITS P1004-10000000-UNITS In Stock ₹ 15,436.45
25000000 UNITS P1004-25000000-UNITS In Stock ₹ 34,899.80
50000000 UNITS P1004-50000000-UNITS In Stock ₹ 52,955.90

P1004 - 1000000 UNITS

₹ 5,282.60

In Stock

Quantity

1

Base Price: ₹ 5,282.60

GST (18%): ₹ 950.868

Total Price: ₹ 6,233.468

biological source

Pseudomonas aeruginosa

Quality Level

200

form

powder

storage condition

(Tightly closed. Dry. )

solubility

water: 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteriafungi

Mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

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Description

  • General description: Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate.
  • Application: Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa†. It also has uses studying multidrug-resistant pathogens††, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
  • Biochem/physiol Actions: Polymyxin B is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant Enterobacteriaceae[4].
  • Features and Benefits: High quality antibiotic suitable for mulitple research applications
  • Preparation Note: Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol.Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.
  • Storage and Stability: As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions.
  • Other Notes: For additional information on our range of Biochemicals, please complete this form.

SAFETY INFORMATION

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves