Polymyxin B sulfate salt
powder, non-animal origin, suitable for cell culture, BioReagent
Manufacturer: Sigma Aldrich
CAS Number: 1405-20-5
Synonym(S): Polymixin, Polymixin B, Polymixin B sulfate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1000000 UNITS | P4932-1000000-UNITS | In Stock | ₹ 7,122.85 |
| 5000000 UNITS | P4932-5000000-UNITS | In Stock | ₹ 16,951.95 |
P4932 - 1000000 UNITS
In Stock
Quantity
1
Base Price: ₹ 7,122.85
GST (18%): ₹ 1,282.113
Total Price: ₹ 8,404.963
product line
BioReagent
Quality Level
200
form
powder
potency
≥6,000 USP units per mg
technique(s)
cell culture | mammalian: suitable
antibiotic activity spectrum
Gram-negative bacteria
Mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O
InChI
1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | TOKU-E Polymyxin B ReadyMade™ Solution, 1405-20-5, 10 ML | -- | ₹ 13,261.80 | |
| | Polymyxin B Solution, 1 mg/mL in Water, MilliporeSigma™ Supelco™ | -- | ₹ 10,831.90 | |
| | U.S. Pharmacopeia Polymyxin B sulphate | 1405-20-5 | 1301.6 g/mol | 200MG | -- | ₹ 28,613.83 | |
| | Polymyxin B Sulfate Pharmaceutical Secondary Standard, MilliporeSigma™ Supelco™ | -- | ₹ 12,200.86 | |
| | Polymyxin B Sulfate, TCI America™ | -- | ₹ 13,321.69 | |
| | Sigma Aldrich Fine Chemicals Biosciences Polymyxin B sulfate United States Pharmacopeia (USP) Reference Standard | 1405-20-5 | 200MG | -- | ₹ 45,791.71 | |
| | TOKU-E Polymyxin B Sulfate, USP, 1405-20-5, 100 MU | -- | ₹ 41,496.60 | |
| | TOKU-E Polymyxin B Sulfate, USP, 1405-20-5, 10 MU | -- | ₹ 10,780.56 | |
| | Enzo Life Sciences Polymyxin B . sulfate (1g). CAS: 1405-20-5 | -- | ₹ 8,953.85 | |
| | Polymyxin B solution | -- | ₹ 8,086.28 |
Related Products
Description
- General description: Polymyxin B is a member of the polymyxin group of antibiotics, obtained from different strains of Bacillus polymyxa and related species. It contains a cyclic heptapeptide unit and a tripeptide side chain, which is N-acylated by a fatty acyl residue. Polymyxin B sulfate salt is generally used for the treatment of Gram-negative bacterial infections.[1]Chemical structure: peptide
- Application: Polymyxin B sulfate salt has been used:for the treatment of BAC-1.2F5 murine macrophages as an LPS (lipopolysaccharide) inhibitor[2] as positive and negative control during microbicidal concentration (MCC) assay[3][4]
- Biochem/physiol Actions: Polymyxin B sulfate has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has been used in studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
- Caution: As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.
- Preparation Note: Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol.
- Other Notes: 1mu,5mu
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves