Transforming Growth Factor-β2 from porcine platelets

Description

• General description: TGF-β2 (transforming growth factor-β2) belongs to the TGF-β superfamily and the gene is mapped to pig (Sus scrofa) chromosome 10p16.[1][2]
• Biochem/physiol Actions: TGF-β2 is responsible for maintaining immune homeostasis.[1] TGF-β2 promotes cellular growth, differentiation and survival.[3] TGF-β2 controls lymphocyte proliferation, apoptosis, hematopoiesis, and embryogenesis.[1] TGF-β2 is a tumor suppress or in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF-β2 prevents NK (natural killer) cells growth as well as B and T cell proliferation.[3] TGF-β2 also greatly inhibits the growth of both normal and transformed epithelial. The growth of lymphoid, fibroblast and keratinocyte cells are also known to be hinder by TGF-β2.[4] TGF-β2 controls intestinal homeostasis by functioning in synergy with the bacterial lipopolysaccharide and thereby maintain interleukin-8.[4]
• Physical form: Lyophilized from a 0.2 μm filtered solution in 25% acetonitrile and 0.1% trifluoroacetic acid containing 0.05 mg bovine serum albumin.
• Analysis Note: The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.