T8904

Thiabendazole

≥99%, powder

Manufacturer: Sigma Aldrich

CAS Number: 148-79-8

Synonym(S): 2-(4-Thiazolyl)benzimidazole

Select a Size

Pack Size SKU Availability Price
100 G T8904-100-G In Stock ₹ 14,500.00
500 G T8904-500-G In Stock ₹ 38,915.88

T8904 - 100 G

₹ 14,500.00

In Stock

Quantity

1

Base Price: ₹ 14,500.00

GST (18%): ₹ 2,610.00

Total Price: ₹ 17,110.00

Quality Level

200

Assay

≥99%

form

powder

color

white to off-white

solubility

DMF: soluble 50 mg/mL

antibiotic activity spectrum

fungiparasites

Mode of action

enzyme | inhibits

SMILES string

c1ccc2[nH]c(nc2c1)-c3cscn3

InChI

1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)

InChI key

WJCNZQLZVWNLKY-UHFFFAOYSA-N

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Description

  • General description: Chemical structure: imidazole
  • Application: Thiabendazole (TBZ) is a broad-spectrum antihelminthic and is used to treat parasitic infections in humans. It is used as an agricultural fungicide and as a food preservative[1]. Thiabendazole has been used as a heavy metal chelating detoxification agent. It is used clinically to treat threadworm, cutaneous larva migrans, visceral larva migrans, and trichinosis[2].
  • Biochem/physiol Actions: Thiabendazole inhibits anaerobic respiration at the level of mitochondrial helminth-specific enzyme. It acts as a quinol-fumarate reductase (QFR) inhibitor in ,C. jejuni and H. pylori, blocking quinol oxidation to quinone. Thiabendazole suppresses egg and larval production and may inhibit the subsequent development of eggs and larvae which are passed in feces[2]. A proposed route of biotransformation of thiabendazole is the CYP1A2-catalyzed hydroxylation to 5-hydroxythiabendazole, which is metabolized to glucuronide and sulfate conjugates[1].
  • Other Notes: Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

SAFETY INFORMATION

Pictograms

GHS09

Signal Word

Warning

Hazard Statements

H410

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves