Description

• Application: N,N′-Disuccinimidyl carbonate (DSC) can be used to synthesize: Various carbamate derivatives from primary and sterically hindered secondary alcohols by alkoxycarbonylation.[1] Active carbonate resins from 4-hydroxymethylpolystyrene and 4-hydroxymethyl-3-nitrobenzamido resins via hydroxy functional groups.[2] Aza-glycinyl dipeptides, important intermediates for the preparation of various azapeptides.[3]It may be also used:In the two-step preparation of 5-(6-(azidomethyl)nicotinamido)pentanoic acid, a copper-chelating picolyl azide derivative.To activate the hydroxyl group of the hapten, γ-hydroxyphenylbutazone (HPBZ) so that HPBZ can effectively bind with human serum albumin(HSA)-immunogen to form a hapten-protein conjugate.
• Other Notes: Convenient reagent for preparing N-succinimidyl esters of N-protected amino acids and other acids;[4] activated carbonate, e.g. synthesis of ureas and carbamates;[5][6] coupling of ligands to proteins (via lysines).[7]