Description

• General description: A convenient reagent for the synthesis of N-succinimidyl esters of N-protected amino acids [1,2,3,4]. Associated Protocols and Technical Articles Guide to Selection of Coupling Reagents Literature references [1] H. Ogura, et al. (1979) Tetrahedron Lett., 20, 4745. [2] H. Ogura, et al. (1981) Tetrahedron Lett., 22, 4817. [3] K. Takeda, et al. (1982) Synth. Commun., 12, 213.[4] K. Takeda, et al. (1983) TetrahedronLett., 24, 4569.
• Application: Utilization in solid-phase peptide synthesis: Discusses the role of N,N′-disuccinimidyl carbonate in solid-phase peptide synthesis, providing insights into its effectiveness in enhancing coupling reactions (Meschaninova et al., 2019). Surface functionalization of polymeric materials: This article explores the application of N,N′-disuccinimidyl carbonate in the surface functionalization of polymers to improve their biocompatibility and interaction with biological molecules (Yakufu et al., 2020). Development of affinity chromatography technologies: Details the use of N,N′-disuccinimidyl carbonate in the development of novel affinity chromatography approaches for protein purification (Hinamoto et al., 2023). Enhancement of polymer properties: Investigates how N,N′-disuccinimidyl carbonate can be used to modify polymer surfaces to enhance their properties, such as increased hydrophilicity and reactivity (Swar et al., 2020).
• Linkage: Replaces: 01-62-0006
• Analysis Note: Color (visual): white to slight yellow to beigeAppearance of substance (visual): powderAssay (HPLC, area%): ≥ 99.0 % (a/a)Water (K. F.): ≤ 0.50 %Identity (IR): passes test
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany