8.51086
Oxyma Pure
≥99.0% (HPLC), for peptide synthesis, Novabiochem®
Manufacturer: Sigma Aldrich
CAS Number: 3849-21-6
Synonym(S): Oxyma Pure, Ethyl cyano(hydroxyimino)acetate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 25 G | 8.51086-25-G | In Stock | ₹ 3,680.01 |
| 100 G | 8.51086-100-G | In Stock | ₹ 11,110.01 |
| 8510860250 | 8.51086-8510860250 | In Stock | ₹ 19,757.88 |
| 8510860500 | 8.51086-8510860500 | In Stock | ₹ 23,320.00 |
| 1 KG | 8.51086-1-KG | In Stock | ₹ 40,380.00 |
| 8510865000 | 8.51086-8510865000 | In Stock | ₹ 1,96,860.00 |
8.51086 - 25 G
In Stock
Quantity
1
Base Price: ₹ 3,680.01
GST (18%): ₹ 662.402
Total Price: ₹ 4,342.412
product name
Oxyma Pure, Novabiochem®
Quality Level
300
product line
Novabiochem®
Assay
≥99.0% (HPLC)
form
crystalline powder
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
mp
130-132 °C
application(s)
peptide synthesis
storage temp.
2-8°C
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | eMolecules Ambeed / Ethyl 2-cyano-2-(hydroxyimino)acetate / 25g / 552750647 / A671796 / / 3849-21-6 / [null] / 142.114 / C5H6N2O3 | -- | ₹ 3,230.75 | |
| | eMolecules Chem-Impex, Inc. | Ethyl (hydroxyimino)cyanoacetate | 1kg | 632265318 | 26426 | | 3849-21-6 | MFCD00002112 | 142.114 | C5H6N2O3 | -- | ₹ 48,448.35 | |
| | Sigma Aldrich Fine Chemicals Biosciences Ethyl (hydroxyimino)cyanoacetate 97% | 3849-21-6 | MFCD00002112 | 50G | -- | ₹ 21,381.44 | |
| | eMolecules Aladdin Scientific Corporation Ethyl (hydroxyimino)cyanoacetate 100g 845137001 E138773 3849-21-6 MFCD00002112 142.114 C5H6N2O3 | -- | ₹ 5,906.21 | |
| | eMolecules Ethyl (hydroxyimino)cyanoacetate | 3849-21-6 | MFCD00002112 | 250g | -- | ₹ 14,921.66 | |
| | Ethyl (hydroxyimino)cyanoacetate | -- | ₹ 14,462.20 - ₹ 37,627.70 | |
| | Ethyl 2-cyano-2-(hydroxyimino)acetate | -- | ₹ 342.24 - ₹ 2,139.00 | |
| | Ethyl 2-cyano-2-(hydroxyimino)acetate | -- | ₹ 427.80 - ₹ 5,133.60 | |
| | 3849-21-6 | Ethyl cyanoglyoxylate-2-oxime | -- | ₹ 427.80 - ₹ 2,481.24 |
Related Products
Description
- General description: Oxyma Pure (Ethyl cyano(hydroxyimino)acetate) is a non-explosive alternative to the canonical peptide coupling additive N-hydroxybenzotriazole (HOBt).[1] When used in place of HOBt in carbodiimide-mediated peptide bond formation, it provides products in higher yields with less racemization. The combination of Oxyma Pure/diisopropylcarbodiimide (DIC) has proven to be particularly effective in microwave-assisted peptide synthesis.[2]The generation of toxic hydrogen cyanide (HCN) from the reaction between Oxyma Pure and DIC has been observed.[3] Fortunately, this side reaction can be eliminated by substituting DIC for the more hindered t-butylethylcarbodiimide.[4]Associated Protocols and Technical ArticlesGuide to Selection of Coupling ReagentsLiterature references:[1] R. Subirós-Funosas, et al. (2009) Chem. Eur. J., 15, 9394[2] J. Collins , et al. (2014) Org . Lett ., 16, 940.[3] A. D. McFarland (2019) Org. Process Res. Dev., 23, 2099.[4] S. R. Manne, et al (2022) Org. Process Res. Dev., 26, 2894.
- Application: Further applications of Oxyma Pure: Use in the synthesis of difficult peptides.[5] As an acidic modifier to prevent aspartimide formation.[6]
- Features and Benefits: Can be used in place of HOBt in carbodiimide-mediated coupling reactions without change of protocolIt gives results comparable to HOAt in step-wise solid-phase synthesisLess epimerization than HOBt in fragment condensation reactions
- Analysis Note: Color (visual): white to slight yellow to beigeAppearance of substance (visual): crystalline powderAssay (HPLC, area%): ≥ 99.0 % (a/a)Identity (IR): passes testSolubility (12,5 mmol in 25 ml DMF): clearly soluble
- Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFETY INFORMATION
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable