Description

• General description: Chelating agent selective for Ca2+. Binds one cation per molecule. Induces apoptosis in pheochromocytoma (PC12) cells.
• Application: Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor.: This study presents a genetically encoded biosensor for real-time monitoring of lysosomal pH changes, potentially enhanced by buffering agents like EGTA. The findings may offer insights into cellular mechanisms influenced by calcium chelation (Ponsford et al., 2021). Comparative Proteomic Analysis of Pleurotus ostreatus Reveals Great Metabolic Differences in the Cap and Stipe Development and the Potential Role of Ca(2+).: The research highlights the role of calcium in fungal development, with EGTA potentially influencing these biological processes through calcium chelation (Zhu et al., 2019).
• Warning: Toxicity: Standard Handling (A)
• Reconstitution: Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
• Other Notes: Lindenboim, L., et al. 1995. J. Neurochem.64, 1054.Bers, D.M. 1982. Am. J. Physiol.242, C404.
• Legal Information: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany