616394
TPEN
Manufacturer: Millipore
CAS Number: 16858-02-9
Synonym(S): TPEN, N,N,Nʹ,Nʹ- tetrakis-(2-Pyridylmethyl)ethylenediamine
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | 616394-100-MG | In Stock | ₹ 18,010.00 |
616394 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 18,010.00
GST (18%): ₹ 3,241.80
Total Price: ₹ 21,251.80
Assay
≥97% (titration)
Quality Level
100
form
solid
reaction suitability
reagent type: chelator
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
tan
solubility
ethanol: 10 mg/mL0.1 M phosphate pH 7.0: 25 μMDMSO: soluble
shipped in
ambient
storage temp.
15-25°C
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | MilliporeSigma™ Calbiochem™ TPEN | -- | ₹ 18,617.00 | |
| | Sigma Aldrich Fine Chemicals Biosciences N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine | 16858-02-9 | MFCD00036918 | 50MG | -- | ₹ 10,795.96 | |
| | eMolecules Ambeed / N1N1N2N2-Tetrakis(pyridin-2-ylmethyl)ethane-12-diamine / 1mg / 761012698 / A539105 / / 16858-02-9 / MFCD00036918 / 424.552 / C26H28N6 | -- | ₹ 2,065.42 | |
| | Cayman Chemical TPEN, 16858-02-9, 10 mg | -- | ₹ 2,703.70 | |
| | N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine | -- | ₹ 11,799.25 - ₹ 19,647.38 | |
| | 1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)- | -- | ₹ 855.60 - ₹ 5,390.28 | |
| | TPEN | -- | ₹ 5,732.52 - ₹ 6,588.12 |
Related Products
Description
- General description: Lipid-soluble heavy metal chelator that crosses artificial and natural membranes. Auxiliary reagent in certain techniques used for measuring free Ca2+ in cells. Has an extremely high affinity for heavy metals but a low affinity for Ca2+ and Mg2+. Induces DNA fragmentation when chelated with Zn2+ and causes apoptosis in thymocytes. Strips heavy metals from liposome-trapped QUIN 2. Shown to be useful in extracting Aβ depostis from Alzheimer′s disease brain tissue.
- Application: Poly(ADP-ribosyl)ation of p53 contributes to TPEN-induced neuronal apoptosis.: This study investigates the role of poly(ADP-ribosyl)ation of the tumor suppressor protein p53 in neuronal apoptosis induced by TPEN, highlighting mechanisms of cell death in neurodegenerative diseases (Kim HL et al., 2015). Essential role of p53 in TPEN-induced neuronal apoptosis.: This article explores the critical involvement of the p53 protein in apoptosis initiated by TPEN in neuronal cells, offering insights into potential therapeutic targets for neuroprotection (Ra H et al., 2009). Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore.: Demonstrates how Clioquinol, similar to TPEN, functions as a zinc ionophore to induce autophagy, particularly in neurological contexts, which may be relevant for understanding TPEN′s mechanisms (Park MH et al., 2011).
- Warning: Toxicity: Standard Handling (A)
- Reconstitution: Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Alternately, acidify (pH ≤3) with HCl for long term storage. Stock solutions are stable for up to 3 months at -20°C.
- Other Notes: Fonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209.Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223.Aballay, A., et al. 1995. Biochem. J.312, 919.Jiang, S., et al. 1995. Lab. Invest.73, 111.Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon33, 539.McCabe, M.J., et al. 1993. Lab. Invest. 69, 101.Hinkle, P.M., et al. 1992. J. Biol. Chem.267, 25553.Baba, A., et al. 1991. Brain Res. 557, 103.Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224.Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol.138, 593.Raspe, E., et al. 1989. Eur. J. Pharmacol.163, 345.Arslan, L.P., et al. 1985. J. Biol. Chem.260, 2719.
- Legal Information: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable