761540

Dibenzocyclooctyne-amine

for Copper-free Click Chemistry

Manufacturer: Sigma Aldrich

CAS Number: 1255942-06-3

Synonym(S): DBCO-NH2, DBCO-amine

Select a Size

Pack Size SKU Availability Price
10 MG 761540-10-MG In Stock ₹ 4,330.00
100 MG 761540-100-MG In Stock ₹ 32,951.30

761540 - 10 MG

₹ 4,330.00

In Stock

Quantity

1

Base Price: ₹ 4,330.00

GST (18%): ₹ 779.40

Total Price: ₹ 5,109.40

Quality Level

100

form

solid

reaction suitability

reaction type: click chemistryreagent type: linker

mp

86-96 °C

functional group

amine

storage temp.

−20°C

SMILES string

NCCC(N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3)=O

InChI

1S/C18H16N2O/c19-12-11-18(21)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13,19H2

InChI key

OCCYFTDHSHTFER-UHFFFAOYSA-N

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Description

  • General description: Dibenzocyclooctyne-amine (DBCO-NH2), is a heterobifunctional linker containing a DBCO moiety commonly used for the site-specific functionalization of nanobodies, enabling the addition of reactive DBCO groups for subsequent click chemistry reactions.[1]
  • Application: Dibenzocyclooctyne-amine can be used as a :Linker to link azide-containing functional groups. It facilitates the formation of linkages through Strain-promoted azide-alkyne cycloaddition reactions (SPAAC)[2]Reagent in the synthesis of N-heterocyclic carbene metal thiolates. It functionalizes the metal complexes and increases their reactivity in the strain-promoted alkyne–azide cycloaddition (SPAAC) reactions[3]Amine functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable