Description

• General description: Phenylboronic acid is a highly stable receptor ligand used in cross-coupling reactions and drug delivery.[1]Phenylboronic acid (PBA) is an organoboronic acid.[2] It behaves as a molecular receptor that can attach to compounds containing cis-diol group.[3] Microwave-assisted Suzuki coupling of aryl chlorides with phenylboronic acid in the presence of Pd/C (catalyst) and water (solvent) has been described.[4] Palladium-catalyzed cross-coupling reaction of phenylboronicacid with haloarenes to afford biaryls has been reported.[5]
• Application: Phenylboronic acid may be employed in the following reactions:Rhodium-catalyzed intramolecular amination.[6] Pd-catalyzed direct arylation.[7] Mizoroki-Heck and Suzuki-Miyaura coupling reactions catalyzed by palladium nanoparticles.[8] Palladium-catalyzed stereoselective Heck-type reaction.[9] Highly effective Palladium-catalyzed arylation Suzuki-Miyaura cross-coupling in water.[10] Phenylboronic acid may be employed as reagent in the preparation of:Ni(II) pincer complex and Pd(II) pyridoxal hydrazone metallacycles as catalysts for the Suzuki-Miyaura cross-coupling reactions.[11][12]N-type polymers for all-polymer solar cells.[13] Novel series of potent and selective mTOR kinase inhibitors.[14] Inhibitors of lactate dehydrogenase against cancer cell proliferation.[15]
• Other Notes: Contains varying amounts of phenylboronic anhydride