N9284
Nitroreductase from Escherichia coli
≥90% (SDS-PAGE), recombinant, expressed in E. coli
Manufacturer: Sigma Aldrich
Synonym(S): NTRA
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | N9284-1-MG | In Stock | ₹ 39,893.40 |
N9284 - 1 MG
In Stock
Quantity
1
Base Price: ₹ 39,893.40
GST (18%): ₹ 7,180.812
Total Price: ₹ 47,074.212
recombinant
expressed in E. coli
Quality Level
200
Assay
≥90% (SDS-PAGE)
form
lyophilized powder
specific activity
≥100 units/mL
mol wt
monomer 24000
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UniProt accession no.
P38489
greener alternative category
, Re-engineered
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Description
- General description: Nitroreductase is a flavoprotein and is encoded by the NfsB gene. It comprises a dimer, with 217 amino acids and active site in each subunit. The structure has FMN and the substrate bound to the enzyme.[1]
- Application: Nitroreductase from Escherichia coli has been used in the conjugation generation with pig liver esterase (PLE).[2] It has also been used in chemiluminescence response studies with probes HyCL-3 and HyCL-4-AM in rat liver microsomes.[3]
- Biochem/physiol Actions: Nitroreductase (NTR) catalyzes the reduction of nitroaromatic substrates and quinones.[1] The mutant F124K of NTR is useful in cancer therapy and improves sensitization of drug CB1954.[4]
- Physical properties: Lyophilized powder containing PBS. Does not contain BSA as excipient
- Unit Definition: One unit will reduce one μmole of Cytochrome C per minute in the presence of Menadione and NADH at pH 7.4 at 37 °C.
- Preparation Note: Produced using animal component-free materials.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable