12-131

Tocris Bioscience™ PD 98059

Manufacturer: Fischer Scientific

CAS Number: 167869-21-8

Select a Size

Pack Size SKU Availability Price
Each of 1 12-131-Each-of-1 In Stock ₹ 10,027.63

12-131 - Each of 1

₹ 10,027.63

In Stock

Quantity

1

Base Price: ₹ 10,027.63

GST (18%): ₹ 1,804.973

Total Price: ₹ 11,832.603

Purity

98%

CAS

167869-21-8

Quantity

1 mg

Molecular Weight (g/mol)

M.W. (Observed): 267.28

Molecular Formula

2-(2-Amino-3-methoxyphenyl)-4 H-1-benzopyran-4-one

Content And Storage

Room Temperature

Product Type

PD 98059

Inhibitors

PD 98059

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Description

  • Inhibitor of mitogen-activated protein kinase kinase (MKK/ MEK)
  • Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 μM)
  • Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction
  • Enhances embryonic stem cell self-renewal.