5545957

Tocris Bioscience™ PD 98059

MEK inhibitor

Manufacturer: Fischer Scientific

CAS Number: 167869-21-8

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Purity

98%

CAS

167869-21-8

Product Type

PD 98059

Inhibitors

PD 98059

Molecular Formula

2-(2-Amino-3-methoxyphenyl)-4 H-1-benzopyran-4-one

Content And Storage

Room Temperature

Molecular Weight (g/mol)

M.W. (Observed): 267.28

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Description

  • Inhibitor of mitogen-activated protein kinase kinase (MKK/ MEK)
  • Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 μM)
  • Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction
  • Enhances embryonic stem cell self-renewal.