35-655-0
Tocris Bioscience™ ONO AE3 208
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 35-655-0-Each-of-1 | In Stock | ₹ 1,19,441.76 |
35-655-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,19,441.76
GST (18%): ₹ 21,499.517
Total Price: ₹ 1,40,941.277
Purity
>98%
Product Type
ONO AE3 208
Inhibitors
ONO AE3 208
Quantity
50 mg
Molecular Weight (g/mol)
404.43
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Description
- High affinity and selective EP4 receptor antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively)
- Displays no affinity for EP1, EP2, DP or IP receptors (Ki >10 μM)
- Inhibits PGE2-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE2 inhibition of natural killer T cell activation
- Suppresses recovery from experimentally-induced colitis and stimulates CD4+ T cell proliferation in C57BL/6 mice
- Also reduces metastasis of mammary tumor cells in a murine model of breast cancer
- Orally active.