Tocris Bioscience™ ONO AE3 208

Description

• High affinity and selective EP4 receptor antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively)
• Displays no affinity for EP1, EP2, DP or IP receptors (Ki >10 μM)
• Inhibits PGE2-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE2 inhibition of natural killer T cell activation
• Suppresses recovery from experimentally-induced colitis and stimulates CD4+ T cell proliferation in C57BL/6 mice
• Also reduces metastasis of mammary tumor cells in a murine model of breast cancer
• Orally active.