49-311-0
Tocris Bioscience™ EG 00229
Manufacturer: Tocris Bioscience™
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Purity
>98%
Product Type
EG 00229
Inhibitors
EG 00229
Quantity
10 mg
Molecular Weight (g/mol)
497.57
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Description
- Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to the NRP1 b1 domain
- Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2
- Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs
- Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro
- Increases chemo-sensitivity of A549 cells in combination with Taxol (Cat
- No
- 1097)
- Blocks pro-tumorigenic M2 polarization in glioma-associated microglia and macrophages and reduces tumor growth and vascularization in NSG mice.