5545952
Tocris Bioscience™ Paroxetine maleate
Highly potent and selective 5-HT uptake inhibitor
Manufacturer: Fischer Scientific
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Purity
>99%
Product Type
Paroxetine maleate
Molecular Weight (g/mol)
445.44
Inhibitors
Paroxetine maleate
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Description
- Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM)
- Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively
- Displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM)
- Antidepressant and anxiolytic in vivo .