5545979
Tocris Bioscience™ PS 1145 dihydrochloride
Selective IKK inhibitor; orally active
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Purity
>98%
Product Type
PS 1145 dihydrochloride
Molecular Weight (g/mol)
395.67
Inhibitors
PS 1145 dihydrochloride
Related Products
Description
- Selective IκB kinase (IKK) inhibitor (IC50 = 100 nM)
- Has no effect on PKA, PKC and CKII activity
- Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells
- Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells
- Enhances TNF-α-induced apoptosis in a multiple myeloma cell line
- Attenuates LPS-induced TNF-α production in vivo
- Orally active.