5545989
Tocris Bioscience™ Reversan
Selective MRP1 and P-gp inhibitor
Manufacturer: Fischer Scientific
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Purity
0.95
Product Type
Reversan
Inhibitors
Reversan
Content And Storage
Store at -20°C
Molecular Weight (g/mol)
441.52
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Description
- Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp)
- Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat
- No
- 2252), vincristine (Cat
- No
- 1257) and etoposide (Cat
- No
- 1226) by 3.8-, 14.6- and 11.6-fold respectively
- Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo
- Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.