5546053
Tocris Bioscience™ TAK 165
Potent and selective ErbB2 inhibitor
Manufacturer: Fischer Scientific
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Purity
>99%
Product Type
TAK 165
Inhibitors
TAK 165
Gene Alias
Mubritinib
Molecular Weight (g/mol)
468.47
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Description
- Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src
- Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo .