5546079
Tocris Bioscience™ Tolvaptan
Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
Tolvaptan
Inhibitors
Tolvaptan
Gene Alias
OPC-41061
Molecular Weight (g/mol)
448.94
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Description
- Potent and selective competitive vasopressin V2 receptor antagonist (Ki values are 0.06 and 12.3 nM for V2 and V1a receptors respectively)
- Decreases urine osmolality and increases serum sodium concentrations
- Delays the onset of end-stage renal disease in a mouse model of polycystic kidney disease
- Exhibits myocardial and renal protective effects in hypertensive heart failure rats
- Orally active.