5546165
Tocris Bioscience™ JNJ 47965567
Potent and selective P2X7 antagonist; brain penetrant
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
JNJ 47965567
Molecular Weight (g/mol)
488.64
Inhibitors
JNJ 47965567
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Description
- Potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively)
- Selective over a panel of 50 other receptors, ion channels and transporters
- Reduces BzATP -induced IL-1β release from monocytes in vitro and from rat brain in vivo
- Attenuates amphetamine -induced hyperactivity in rats
- Brain penetrant.