5546184
Tocris Bioscience™ Rhosin hydrochloride
Rho GTPase inhibitor
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
Rhosin hydrochloride
Molecular Weight (g/mol)
394.86
Inhibitors
Rho GTPase Inhibitors
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Description
- Rho GTPase inhibitor (Kd = 354 nM)
- Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF
- Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs
- Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro
- Also induces neurite outgrowth in synergy with NGF.