5546199
Tocris Bioscience™ TC-S 7006
Potent and selective Tpl2 (Cot; MAP3K8) inhibitor
Manufacturer: Fischer Scientific
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Purity
>99%
Product Type
TC-S 7006
Molecular Weight (g/mol)
404.83
Inhibitors
TC-S 7006
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Description
- Potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50 nM)
- Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR
- Inhibits LPS-induced TNF-α secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro
- Also reduces cytolytic activity of human CD8+ cytotoxic T lymphocytes
- Cell permeable.