32-451-95MG
MilliporeSigma™ Calbiochem™ InSolution™ eIF4E/eIF4G Interaction Inhibitor, 4EGI-1
Manufacturer: MilliporeSigma™
CAS Number: 315706-13-9
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 32-451-95MG-Each-of-1 | In Stock | ₹ 16,024.53 |
32-451-95MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,024.53
GST (18%): ₹ 2,884.415
Total Price: ₹ 18,908.945
Formulation
A 25 mM (5mg/443μL) solution of eIF4E/eIF4G Interaction Inhibitor, 4EGI-1
Target Proteins
eIF4E
Molecular Formula
C18H12Cl2N4O4S
Content And Storage
Avoid Freeze-Thaw Cycles, Hygroscopic, Protect from Light
Quantity
5 mg
Description
95% by HPLC (sum of two isomers)
CAS
315706-13-9
Formula Weight
451.3g/mol
Form
Liquid
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-19831 10mg , 4EGI-1 CAS:315706-13-9 Purity:>98% | -- | ₹ 14,194.40 | |
| | MilliporeSigma™ Calbiochem™ eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 | -- | ₹ 25,626.93 | |
| | Selleck Chemical LLC 4EGI-1 10mg 315706-13-9 | -- | ₹ 20,226.38 | |
| | Enzo Life Sciences 4EGI-1 (2mg). CAS: 315706-13-9 | -- | ₹ 29,026.23 | |
| | 315706-13-9 | eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 | -- | ₹ 1,026.72 - ₹ 31,058.28 |
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Description
- A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; K D = 25μM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation
- Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-x L in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC 50 ∽25μM)
- Shown to be brain permeant and reduce neuroligin protein levels, and restore L-LTP threshold and rescue autistic-like behaviours in Eif4ebp2 knockout mice.