MilliporeSigma™ Calbiochem™ Fibroblast Growth Factor-2 Inhibitor, NSC37204

Description

• A small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC 50 = 1.3μM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC 50 = 24.0 &plusmn6.9μM), in vitro
• It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC 50 = 20.3μM &plusmn5.9μM)
• In CAM assays in vivo , where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5μg) reduces the mean number of blood vessels entering the sponge from 26 &plusmn4 (FGF-2 alone) to 10 &plusmn2 (FGF-2 + NSC37203).