38-558-110MG
MilliporeSigma™ Calbiochem™ 11beta-HSD1 Inhibitor, 10j
Manufacturer: MilliporeSigma™
CAS Number: 1009373-58-3
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 38-558-110MG-Each-of-1 | In Stock | ₹ 23,921.72 |
38-558-110MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 23,921.72
GST (18%): ₹ 4,305.91
Total Price: ₹ 28,227.63
Color
White
CAS
1009373-58-3
Formula Weight
501.46g/mol
Form
Solid
Description
95% by HPLC
Molecular Formula
C26H33BrN2O3
Solubility
DMSO
Quantity
10 mg
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Description
- A cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC 50 of 1.6nM and 5.3 nM) in enzyme and human adipocyte assays, respectively
- Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays
- 11β-HSD1 activity in the presence of 10j2 (10mg/kg in animals p.o.) results in an ˜ 80% reduction in the concentration of plasma cortisol over vehicle treated controls.